Private Anthony Carmine (voiced by Michael Gough) is one of the original members of Delta squad and the middle of the three Carmine brothers. He possesses a bright and gung-ho attitude. He serves with Delta squad through earlier segments of Gears of War, but is shot in the head and killed by a Locust sniper while dealing with a weapons malfunction. When Marcus is having a nightmare about his father's "death," he imagines Anthony and his brother Benjamin are fighting with him.

His younger brother, Benjamin, fought in Gears of War 2 and after Ben died as well, Clayton, the third and eldest Carmine brother, got a tattoo of Anthony and Benjamin on his biceps to defend their honor.